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Engineered cell lines for fish health research

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Date
2018
Author
Collet, B.
Collins, C.
Lester, K.
Is part of
Developmental and Comparative Immunology
Size or duration
34-40
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Abstract
As fish farming continues to increase worldwide, the related research areas of fish disease and immunology are also expanding, aided by the revolution in access to genomic information and molecular technology. The genomes of most fish species of economic importance are now available and annotation based on sequence homology with characterised genomes is underway. However, while useful, functional homology is more difficult to determine, there being a lack of widely distributed and well characterised reagents such as monoclonal antibodies, traditionally used in mammalian studies, to help with confirming functions and cellular interactions of fish molecules. In this context, fish cell lines and the possibility of their genetic engineering offer good prospects for studying functional genomics with respect to fish diseases. In this review, we will give an overview of available permanently genetically engineered fish cell lines, as cell-based reporter systems or platforms for expression of endogenous immune or pathogen genes, to investigate interactions and function. The advantages of such systems and the technical challenge for their development will be discussed.
DOI
https://doi.org/10.1016/j.dci.2017.01.013
Link
https://hdl.handle.net/20.500.12594/10540
Citation
Collet, B., Collins, C. & Lester, K. (2018). Engineered cell lines for fish health research. Developmental and Comparative Immunology, 80, 34-40.
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©Research Scotland Consortium
c/o RGBE 20a Inverleith Row
EH3 5LR
Edinburgh, Scotland, UK

Tel: 0131 248 2850
Email: info@ResearchScotland.ac.uk
Items in Research Scotland are protected by copyright with all rights reserved unless otherwise indicated.
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